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Prof. Kristina
Woods PhD Guest-Professor
| | | | In my research I use THz (TeraHertz) spectroscopy to explore picosecond time-scale global and local intermolecular associations in proteins and other biologically-relevant macromolecules. I combine experimental measurements with computational analyses to detect and characterize these thermally-induced, collective fluctuations that have been hypothesized to play a central role in driving biochemical reactions such as enzymatic activity, ligand binding, and protein-protein recognition interactions.
Selected Publications
Woods, K.N., Pfeffer, J., Dutta, A., Klein-Seetharaman, J. (2016). Vibrational resonance, allostery, and activation in rhodopsin-like G protein-coupled receptors. Scientific Reports 6, 37290.
Woods, K.N., Pfeffer, J. (2015). Using THz spectroscopy, evolutionary network analysis methods, and MD simulation to map the evolution of allosteric communication pathways in c-type lysozymes. Molecular Biology and Evolution 33, 40-61. doi: 10.1093/molbev/msv178
Woods, K.N. (2014). Using THz time-scale infrared spectroscopy to examine the role of collective, thermal fluctuations in the formation of myoglobin allosteric communication pathways and ligand specificity. Soft Matter 10(24), 4387-4402. doi: 10.1039/C3SM53229A
Woods, K.N. (2014) THz time scale structural rearrangements and binding modes in lysozyme-ligand interactions. Journal of Biological Physics 40(2), 121-137. doi:10.1007/s10867-014-9341-4
Woods, K.N. (2014) The glassy state of crambin and the THz time scale protein-solvent fluctuations possibly related to protein function. BMC Biophysics 7:8. doi:10.1186/s13628-014-0008-0
| | | | Room: | | L142 | | | | Phone: | | +49-89-2180-9252 (office)
| | | | E-mail: | | kristina.woods@physik.lmu.de | | | | Homepage: | | http://knwoods.com/ (private)
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