BMOLogo
Publications

LMU München
Fakultät für Physik


Home

General
Research
Funding
Members
Publications
  All Publications
  PhD Theses
  Master Theses
  Search
  i Search
Lectures/Seminars
Conferences
Vacancies
Search

Internal




Impressum
(c) 2002 BMO

"Photothermal detection of gold nanoparticles using phase-sensitive optical coherence tomography"
Desmond C. Adler, Shu-Wei Huang, Robert Huber, and James G. Fujimoto
Optics Express 16, 4376 (2008)


Abstract:
The detection of a gold nanoparticle contrast agent is demonstrated using a photothermal modulation technique and phase sensitive optical coherence tomography (OCT). A focused beam from a laser diode at 808 nm is modulated at frequencies of 500 Hz - 60 kHz while irradiating a solution containing nanoshells. Because the nanoshells are designed to have a high absorption coefficient at 808 nm, the laser beam induces small-scale localized temperature oscillations at the modulation frequency. These temperature oscillations result in optical path length changes that are detected by a phase-sensitive, swept source OCT system. The OCT system uses a double-buffered Fourier domain mode locked (FDML) laser operating at a center wavelength of 1315 nm and a sweep rate of 240 kHz. High contrast is observed between phantoms containing nanoshells and phantoms without nanoshells. This technique represents a new method for detecting gold nanoparticle contrast agents with excellent signal-to-noise performance at high speeds using OCT. (C) 2008 Optical Society of America.

BMO authors (in alphabetic order):
Robert Huber

Assoziierte Projekte:
Optical Coherent Ranging and Optical Coherence Tomography (OCT): Imaging and profilometry with rapidly frequency swept laser sources
Fourier Domain Mode Locking (FDML): Spectral mode locking in optics and applications


WWW-Version

mailto: webmaster
Letzte Änderung: 2016-09-14 13:34