"Ultrafast Hemithioindigo-based Peptide-Switches"T. Cordes, C. Elsner, T. T. Herzog, C. Hoppmann, T. Schadendorf, W. Summerer, K. Rück-Braun, W. Zinth
Chemical Physics, 2009, 358, pp 103-110
Four newly synthesized Hemithioindigo-based peptide-switches with changing meta/para substitution-pattern within the stilbene-part of the molecule are characterized with time resolved absorption spectroscopy. The different substances undergo a light-induced Z/E isomerization: the reaction proceeds on a picosecond timescale with time constants < 50 ps for the Z->E photoreaction and < 10 ps for the inverse process from E->Z. The reaction times strongly depend on the specific substitution-pattern: fast reaction dynamics (< 10 ps) are observed for the direct attachment of electron donating groups in the para-position. The molecular mechanism of the isomerization process can be described with the same reaction model as used for related systems. The presented Hemithioindigos are hence promising alternatives to Azobenzene-switches due to their fast switching speed, improved spectral characteristics and an improved stability.
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