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"Mechanistic Insights into the Hydrolysis of a Nucleoside Triphosphate Model in Neutral and Acidic Solution" Rachel Glaves, Gerald Mathias, and Dominik MarxJ. Am. Chem. Soc., 134 6995–7000 (2012) Abstract: Nucleoside triphosphate hydrolysis is an essential component of all living systems. Despite extensive research, the exact modus and mechanism of this ubiquitous reaction still remain elusive. In this work, we examined the detailed hydrolysis mechanisms of a model nucleoside triphosphate in acidic and neutral solution by means of ab initio simulations. The timescale of the reaction was accessed through use of an accelerated sampling method, metadynamics. Both hydrolyses were found to proceed via different mechanisms, the acidic system reacted by means of concerted general acid catalysis (found to be a so-called DNANAHDxh mechanism) whereas the neutral system reacted by way of a different mechanism (namely DN*ANDxhAH). A neighbouring water molecule took on the role of a general base in both systems which has not been seen before, but is a highly plausible reaction path, meaning that substrate-assisted catalysis was not observed in the bulk water environment. BMO authors (in alphabetic order): Gerald Mathias  WWW-Version |
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Letzte Änderung: 2016-09-14 13:34
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