"In situ structural and microangiographic assessment of human skin lesions with high-speed OCT"Cedric Blatter, Jessika Weingast, Aneesh Alex, Branislav Grajciar, Wolfgang Wieser, Wolfgang Drexler, Robert Huber, and Rainer A. Leitgeb
Biomedical Optics Express, Vol. 3, Issue 10, pp. 2636-2646 (2012)
We demonstrate noninvasive structural and microvascular contrast imaging of different human skin diseases in vivo using an intensity difference analysis of OCT tomograms. The high-speed swept source OCT system operates at 1310 nm with 220 kHz A-scan rate. It provides an extended focus by employing a Bessel beam. The studied lesions were two cases of dermatitis and two cases of basal cell carcinoma. The lesions show characteristic vascular patterns that are significantly different from healthy skin. In case of inflammation, vessels are dilated and perfusion is increased. In case of basal cell carcinoma, the angiogram shows a denser network of unorganized vessels with large vessels close to the skin surface. Those results indicate that assessing vascular changes yields complementary information with important insight into the metabolic demand.
BMO authors (in alphabetic order):
Optical Coherent Ranging and Optical Coherence Tomography (OCT): Imaging and profilometry with rapidly frequency swept laser sources
Fourier Domain Mode Locking (FDML): Spectral mode locking in optics and applications