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Time-Encoded (TICO) Raman spectroscopy and microscopy
The Time-encoded Raman approach uses rapidly wavelength swept FDML lasers in combination with a narrowband, actively modulated pump laser to encode and detect the Raman spectra directly in time. The approach using a wavelength swept Probe laser enables recording spectral points sequentially in time, allowing for laser line width limited spectral resolution paired with broadband coverage. The obtained spectra can further be used to create hyperspectral Raman microscopy images of biological samples, therefore providing a molecular imaging contrast. This new approach using wavelength swept lasers enables is advantageous since it uses fiber-based lasers which can also be used for other imaging modalities, like recoding a confocal image or an OCT volume in parallel.
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