BMOLogo
Publications

LMU München
Fakultät für Physik


Home

General
Research
Members
Publications





Impressum
(c) 2002 BMO

"Picosecond conformational transition and equilibration of a cyclic peptide "
J. Bredenbeck, J. Helbing, A. Sieg, T. Schrader, W. Zinth, C. Renner, R. Behrendt, L. Moroder, J. Wachtveitl, P. Hamm
Proc. Natl. Acad. Sci. USA, 100 (2003) 11, 6452-6457 + 10580


Abstract:
Ultrafast IR spectroscopy is used to monitor the nonequilibrium backbone dynamics of a cyclic peptide in the amide I vibrational range with picosecond time resolution. A conformational change is induced by means of a photoswitch integrated into the peptide backbone. Although the main conformational change of the backbone is completed after only 20 ps, the subsequent equilibration in the new region of conformational space continues for times >16 ns. Relaxation and equilibration processes of the peptide backbone occur on a discrete hierarchy of time scales. Albeit possessing only a few conformational degrees of freedom compared with a protein, the peptide behaves highly nontrivially and provides insights into the complexity of fast protein folding.

BMO authors (in alphabetic order):
Tobias Schrader
Arne Sieg
Josef Wachtveitl
Wolfgang Zinth

Assoziierte Projekte:
Peptide and protein folding


mailto: webmaster
Letzte Änderung: 2016-09-14 13:34