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"Early Events of DNA Photodamage" W. J. Schreier, P. Gilch, W. Zinth
Annu. Rev. Phys. Chem.66 (2015) 497-519
Abstract: Ultraviolet (UV) radiation is a leading external hazard to the integrity of
DNA. Exposure to UV radiation triggers a cascade of chemical reactions,
and many molecular products (photolesions) have been isolated that are potentially
dangerous for the cellular system. The early steps that take place
after UV absorption by DNA have been studied by ultrafast spectroscopy.
The review focuses on the evolution of excited electronic states, the formation
of photolesions, and processes suppressing their formation. Emphasis
is placed on lesions involving two thymine bases, such as the cyclobutane
pyrimidine dimer, the (6-4) lesion, and its Dewar valence isomer.
BMO authors (in alphabetic order): Peter Gilch Wolfgang Schreier Wolfgang Zinth
WWW-Version
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