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AG Tavan - Projects

LMU München
Fakultät für Physik

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(c) 2002 BMO

Molecular Modeling and Pattern Recognition for Computational Analysis and Support of Screening Experiments Aiming at the Development of Anti-TSE pharmaceuticals

(Data based Modelling and Neuroinformatics)

Transmissible Spongiform Encephalopathies (TSE), including Creutzfeldt-Jakob disease (CJD) in human, Scrapie in sheep and Bovine Spongiform Encephalopathy (BSE) in cattle, are invariably fatal neurodegenerative diseases. This project is part of an interdisciplinary research project for the systematic development of anti-TSE pharmaceuticals. Using methods of pattern recognition and molecular modelling we support the experimental approaches of our partners.

This project is funded by the Bundesminissterium für Bildung und Forschung and is part of the jointproject Systematic Development of New Compounds for the Causal Therapy of Prion Diseases.

Our partners in this joint project:
Uwe Bertsch, Armin Giese, Hans A. Kretzschmar, LMU, Zentrum für Neuropathologie und Prionforschung
Markus Geißen, Martin Eiden, Martin Groschup, FLI Riems - Federal Research Institute for Animal Health, Institute for Novel and Emerging Infectious Diseases (INEID)
Konstanze F. Winklhofer, Jörg Tatzelt, Max-Planck-Institute for Biochemistry, Department for Cellular Biochemistry, AG Tatzelt, Martinsried
Hermann Schätzl, TUM, Institut für Virologie, Prion Research Group
Gerda Wünsch, Shneh Sethi, Jochen Herms, LMU, Zentrum für Neuropathologie und Prionforschung
Raj Narlawar, Boris Schmidt, Institute for Organic Chemistry, TU Darmstadt

Previous coworkers:

Paul Tavan
Thomas Hirschberger

"Piperazine derivatives inhibit PrP/PrPres propagation in vitro and in vivo"
Fabienne Leidel, Martin Eiden, Markus Geissen, Thomas Hirschberger, Paul Tavan, Armin Giese, Hans A. Kretzschmar, Hermann Schätzl, and Martin H. Groschup

Biochem. Biophys. Res. Commun. 445, 23-29 (2014).

Details

"Anle138b: a novel oligomer modulator for disease‑modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease"
Jens Wagner, Sergey Ryazanov, Andrei Leonov, Johannes Levin, Song Shi, Felix Schmidt, Catharina Pri, Francisco Pan‑Montojo, Uwe Bertsch, Gerda Mitteregger‑Kretzschmar, Markus Geissen, Martin Eiden, Fabienne Leidel, Thomas Hirschberger, Andreas A. Deeg, Julian J. Krauth, Wolfgang Zinth, Paul Tavan, Jens Pilger, Markus Zweckstetter, Tobias Frank, Mathias Bähr, Jochen H. Weishaupt, Manfred Uhr, Henning Urlaub, Ulrike Teichmann, Matthias Samwer, Kai Bötzel, Martin Groschup, Hans Kretzschmar, Christian Griesinger, Armin Giese

Acta Neuropathologica 125, 795-813 (2013).

Details

"Systematic identification of anti-prion drugs by high-throughput screening based on scanning for intensely fluorescent targets"
Uwe Bertsch, Konstanze F. Winklhofer, Thomas Hirschberger, Jan Bieschke, Petra Weber, F. Ulrich Hartl, Paul Tavan, Jörg Tatzelt, Hans A. Kretzschmar, and Armin Giese

J. Virol. 79 7785-7791 (2005)

Details

"Single Molecule Analysis of Protein Aggregation and Prions by SIFT"
Hans A. Kretzschmar, Uwe Bertsch, Konstanze F. Winklhofer, Thomas Hirschberger, Jan Bieschke, Petra Weber, F. Ulrich Hartl, Paul Tavan, Jörg Tatzelt, and Armin Giese

J Neuropathol Exp Neurol 64 441 (2005)

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Letzte Änderung: 2023-10-31 16:51
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