| Publications: | | "Piperazine derivatives inhibit PrP/PrPres propagation in vitro and in vivo"
Fabienne Leidel, Martin Eiden, Markus Geissen, Thomas Hirschberger, Paul Tavan, Armin Giese, Hans A. Kretzschmar, Hermann Schätzl, and Martin H. Groschup
Biochem. Biophys. Res. Commun. 445, 23-29 (2014). details
"Anle138b: a novel oligomer modulator for disease‑modifying therapy of neurodegenerative diseases such as prion
and Parkinson's disease"
Jens Wagner, Sergey Ryazanov, Andrei Leonov, Johannes Levin, Song Shi, Felix Schmidt, Catharina Pri, Francisco Pan‑Montojo, Uwe Bertsch, Gerda Mitteregger‑Kretzschmar, Markus Geissen, Martin Eiden, Fabienne Leidel, Thomas Hirschberger, Andreas A. Deeg, Julian J. Krauth, Wolfgang Zinth, Paul Tavan, Jens Pilger, Markus Zweckstetter, Tobias Frank, Mathias Bähr, Jochen H. Weishaupt, Manfred Uhr, Henning Urlaub, Ulrike Teichmann, Matthias Samwer, Kai Bötzel, Martin Groschup, Hans Kretzschmar, Christian Griesinger, Armin Giese
Acta Neuropathologica 125, 795-813 (2013). details
"Diphenyl-pyrazole derived compounds increase survival time of mice after prion infection"
Fabienne Leidel, Martin Eiden, Markus Geissen, Hans A. Kretzschmar, Armin Giese, Thomas Hirschberger, Paul Tavan, Hermann M. Schätzl, and Martin H. Groschup
Antimicrob. Agents and Chemother. 55, 4774–4781 (2011). details
"From high-throughput cell culture screening to mouse model: Identification of new inhibitor classes against prion disease"
Markus Geissen, Fabienne Leidel, Martin Eiden,Thomas Hirschberger, Christine Fast, Uwe Bertsch, Paul Tavan, Armin Giese, Hans A. Kretzschmar, Hermann M. Schätzl, and Martin H. Groschup
ChemMedChem 6, 1928 – 1937 (2011). details
"Identification of Anti-prion Compounds as Efficient Inhibitors of Polyglutamine Protein Aggregation in a Zebrafish Model"
Niclas W. Schiffer, Sarah A. Broadley, Thomas Hirschberger, Paul Tavan, Hans A. Kretzschmar, Armin Giese, Christian Haass, F. Ulrich Hartl, and Bettina Schmid
J. Biol. Chem. 282, 9195-9203 (2007) details
"Structural Instability of the Prion Protein upon M205S/R Mutations Revealed by Molecular Dynamics Simulations"
Thomas Hirschberger, Martina Stork, Bernhard Schropp, Konstanze F. Winklhofer, Jörg Tatzelt, and Paul Tavan
Biophys. J. 90, 3908-3918 (2006). details
"Extracting Markov models of peptide conformational dynamics from simulation data"
Verena Schultheis, Thomas Hirschberger, Heiko Carstens, and Paul Tavan
J. Chem. Theory Comput. 1, 515 - 526 (2005). details
"Systematic identification of anti-prion drugs by high-throughput screening based on scanning for intensely fluorescent targets"
Uwe Bertsch, Konstanze F. Winklhofer, Thomas Hirschberger, Jan Bieschke, Petra Weber, F. Ulrich Hartl, Paul Tavan, Jörg Tatzelt, Hans A. Kretzschmar, and Armin Giese
J. Virol. 79 7785-7791 (2005) details
"Single Molecule Analysis of Protein Aggregation and Prions by SIFT"
Hans A. Kretzschmar, Uwe Bertsch, Konstanze F. Winklhofer, Thomas Hirschberger, Jan Bieschke, Petra Weber, F. Ulrich Hartl, Paul Tavan, Jörg Tatzelt, and Armin Giese
J Neuropathol Exp Neurol 64 441 (2005) details
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